A number of different methods of plasmapheresis are used currently in clinical practice. Most of them, however, require centrifuges or other stationary apparatus. Nevertheless, some therapeutic and prophylactic institutions do not have such devices - in hard-to-reach territories without electricity facilities, for example. Only after organization of the industrial production of the first domestic membrane plasma filtrers PFM-800 and development of the technique of non-apparatus membrane plasmapheresis UBM-01-"PF SPb" (the developer and the manufacturer JSC "Plasmofilter", St. Petersburg, patent No. 2113240 dated 05.05.95) procedures of membrane plasmapheresis have became accessible for serial medical institutions, including regional hospitals, medical maternity units, etc.
The proposed "non-apparatus" method does not require power supplies and equipment - only transfusion rack is needed. Blood exfusion and reinfusion of concentrated red blood cells is performed under the gravity forces using a one-needle scheme. The benefits of the method are simplicity and safety. There are no needs in "uncoupling" of the system elements during the procedure, that makes impossible mistakes of blood "cross-transfusions" and excludes the possibility of infection of patients and medical staff.
One team (the doctor and the nurse) may conduct procedures of membrane plasmapheresis up to five patients simultaneously, especially in the case of mass defeats for emergency detoxification in centers of destructions in the "disaster medicine". Method of non-apparatus membrane plasmapheresis could be successfully conducted in outpatient, and even in urgent circumstances, in field conditions.
The device is Design and maintenanceed to conduct procedures of membrane plasmapheresis without additional equipment and power supplies. The method of non-apparatus membrane plasmapheresis is unique, has no analogues in world practice. The technique could be applied even in small hospitals and their departments, in medical unit and even in ambulance and disaster medicine, in military field conditions.


  The arrangement of elements of non-apparatus membrane plasmapheresis UBM-01 "PF SPb" on the infusion stand.

The method of non-apparatus membrane plasmapheresis device using UBM-01-"PF SPb" is based on the siphon blood sampling, bypassing a plasma filter, into polymer container with the anticoagulant solution similar to the blood donor procedures of blood banking (the phase of blood sampling).
After filling the container with the blood, it is moved to the top position and the blood return phase starts. Blood flows, under the gravity force, back into the same vein, passing through the plasma filter. Plasma output from plasma filter amounts approximately 1/3 of the volume of flowing blood.

When container is empty, it is moved down again, the required volume of the anticoagulant is admixed and the next cycle of blood withdrawal begins.
Saline or other plasma expanders are added to the working container as required.
Recommended transmembrane pressure in plasma filter is about 130-150 mm Hg.
It consists of a positive pressure in the blood chambers, 70-80 mm Hg created by lifting the blood container at 1 m above the level of plasma filter (h1), and of a negative pressure in plasma chambers. Putting down the plasma container below 1 m of the plasma filter (h2), one can create a negative pressure in plasma chambers about 70-80 mm Hg.


  Scheme of the extracorporeal circuit
1-6, 25, 26 - clips;
7-9 - filter-dropper;
10 - needle or venous catheter;
11 - needle for isotonic sodium chloride solution;
12 - needle for an anticoagulant;
13 - branch line for blood sampling;
14 - connector (needle) for plasma output;
15-18 - tees;
19 - container with isotonic NaCl solution;
20 – container with an anticoagulant;
21 - membrane plasma filter (PFM);
22 - container for plasma;
23 - container for collecting blood;
24 - line for air release.


User Manual UBM-01-"PF-SPb" (in Russian, 23 pages)
download: pdf (971 Kb); djvu (465 Kb).
Leninskiy pr., bld.140, Saint Petersburg, 198216, Russia, tel. +7 (812) 376-9079, +7 (812) 376-9070; +7 (921) 9168147 mob.; fax: +7 (812) 376-9079
Design and maintenance: Eugene Vovenko
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